Some general signs Extravasation refers to the leakage of injected drugs from blood vessels causing damage to the surrounding tissues
3) Extravasation can also be recognized more quickly when promethazine is diluted than if the drug is given in a smaller volume
The impact of extravasation is mostly determined by the localisation and volume of extravasation, but the physicochemical properties of the drugs are also
2,22
Guidelines for the treatment of extravasation injuries facilitate decision making, given their time-sensitive nature
Promethazine is acidic and can cause a devastating extravasation, particularly if administered inadvertently through the arteriolar route
2 Delayed diagnosis or ineffective interventions can result in extended
Promethazine is acidic and can cause a devastating extravasation, particularly if administered inadvertently through the arteriolar route
Extravasation is the leakage of intravenous solutions into surrounding tissues, which can be influenced by drug properties, infusion techniques, and patient-related risk factors
Treatment of a vesicant extravasation includes immediate cessation of infusion, aspiration of as much extravasated drug as possible through the still-intact catheter, and attempts for the aspiration of the extravasated agent in the surrounding tissue
2 Delayed diagnosis or ineffective interventions can result in extended necrosis, or the need for plastic surgery 6 or even amputation
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, nerve block) and systemic heparin therapy have been used to manage inadvertent intra-arterial administration and extravasation of promethazine based on animal data
Promethazine is formulated with phenol and has a pH between 4 and 5
Promethazine hydrochloride is a phenothiazine derivative which possesses antihistaminic, sedative, antimotion-sickness, antiemetic, and anticholinergic effects
Early identification and appropriate management of extravasation is crucial in order to prevent serious adverse outcomes ; Promethazine Potassium chloride >40 mmol/L MD et al
Extravasation injury from cancer chemotherapy is reported to be 11% in children and 22% in adults
The phase IV clinical study analyzes which people take Phenergan and have Extravasation
Promethazine (PHENERGAN) Disadvantage – Can cause tissue damage if extravasation, so generally shouldn't be given intravenously
Mode of Action: Common Trade Names: Phenadoz; Phenergan; Promethegan; Adult Dosing
5-25mg PO/IM/IV q4-6h extravasation/tissue damage (IV use > IM use) apnea; respiratory depression; respiratory depression, fatal (infants)
Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot
During an infusion of DHE, the patient developed acute pain near the catheter insertion site due to active extravasation of IV DHE