Cell culture tamoxifen versus 4ht

In my cell culture of primary keratinocytes and a carcinoma cell line, TAM (4OH, dissolved in EtOH While estrogen sensitivity was not restored in endoxifen- and ICI-resistant cells, the 4HT-resistant cells experienced a period of estrogen hypersensitivity following withdrawal. We substantiated this conclusion by showing that treatment of cancer cells with 4HT increased Nrf2 stability and gene transcription through the ARE

2024-03-28
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  1. Mouse myocytes from two separate cell preparations were analyzed
  2. RUNX1-ER/PGK
  3. BxPC-3 cells (ATCC CRL-1687), were maintained in RPMI-1640 medium