Data to support use of alternatives to penicillin in treating primary and secondary syphilis are limited
4 million U of benzathine penicillin G, with studies reporting
Azithromycin as a single 2-g oral dose has been effective for treating early syphilis in some settings
Does a single 2-gram oral dose of azithromycin treat early syphilis? Curr Infect Dis Rep
4-MU intramuscular dose of penicillin G
Clinical manifestations
Pediatric dosing: Benzathine penicillin G 50,000 units/kg IM, up to the adult dose of 2
Azithromycin treatment failures in syphilis infections--San Francisco, California, 2002-2003
Azithromycin is used to treat certain bacterial infections in many different parts of the body
For example, a multicenter trial of a single dose (2 g) of azithromycin for early syphilis is under way in Madagascar and in the United States in Birmingham, Alabama; Chapel Hill, North Carolina Objectives: Effectiveness of single-dose azithromycin (2 g) in the treatment of early syphilis among HIV-infected patients has rarely been evaluated in the era of combination ART
If treating with cefixime, and chlamydial infection has not been excluded, providers should treat for chlamydia with doxycycline 100 mg orally twice daily for 7 days
Azithromycin compared with penicillin G benzathine for treatment of incubating
Each of these subjects had received azithromycin
A 2010 study by Hook et al showed a single dose of azithromycin (2 g PO) to be equivalent to the treatment of choice, benzathine penicillin G (2
Azithromycin belongs to the class of drugs known as macrolide antibiotics
4 million units IM each at 1-week intervals * Recommendations for treating syphilis in persons with HIV and pregnant women are discussed elsewhere in this report (see
Dosing Considerations This review showed clearly that a single dose of azithromycin, orally, is as effective as the 2
• Ceftriaxone, IM, 250 mg immediately as a single dose
A single oral dose of azithromycin is non-inferior to benzathine benzylpenicillin and avoids the need for injection equipment and medically trained personnel
† Doxycycline 200 mg daily (either 100 mg twice daily or as a single 200 mg dose) orally for 14 days Late latent (i
Syphilis is a sexually transmitted disease found only in humans, which is caused by a spirochete (Treponema pallidum)